Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses.
Identifieur interne : 001857 ( Main/Exploration ); précédent : 001856; suivant : 001858Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses.
Auteurs : Spencer C. Maughan [Royaume-Uni] ; Maciej Pasternak ; Narelle Cairns ; Guy Kiddle ; Thorsten Brach ; Renee Jarvis ; Florian Haas ; Jeroen Nieuwland ; Benson Lim ; Christopher Müller ; Enrique Salcedo-Sora ; Cordula Kruse ; Mathilde Orsel ; Rüdiger Hell ; Anthony J. Miller ; Patrick Bray ; Christine H. Foyer ; James A H. Murray ; Andreas J. Meyer ; Christopher S. CobbettSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antipaludiques (pharmacologie), Arabidopsis (génétique), Arabidopsis (métabolisme), Cadmium (pharmacologie), Chloroquine (pharmacologie), Femelle (MeSH), Glutathion (métabolisme), Gènes de plante (MeSH), Homéostasie (MeSH), Modèles biologiques (MeSH), Mutation (MeSH), Ovocytes (métabolisme), Plasmodium falciparum (effets des médicaments et des substances chimiques), Plasmodium falciparum (génétique), Plasmodium falciparum (métabolisme), Protéines d'Arabidopsis (génétique), Protéines d'Arabidopsis (métabolisme), Protéines de protozoaire (génétique), Protéines de protozoaire (métabolisme), Protéines de transport membranaire (génétique), Protéines de transport membranaire (métabolisme), Protéines recombinantes (génétique), Protéines recombinantes (métabolisme), Résistance aux substances (MeSH), Stress physiologique (MeSH), Techniques in vitro (MeSH), Végétaux génétiquement modifiés (MeSH), Xenopus (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Plasmodium falciparum.
- génétique : Arabidopsis, Plasmodium falciparum, Protéines d'Arabidopsis, Protéines de protozoaire, Protéines de transport membranaire, Protéines recombinantes.
- métabolisme : Arabidopsis, Glutathion, Ovocytes, Plasmodium falciparum, Protéines d'Arabidopsis, Protéines de protozoaire, Protéines de transport membranaire, Protéines recombinantes.
- pharmacologie : Antipaludiques, Cadmium, Chloroquine.
- Animaux, Femelle, Gènes de plante, Homéostasie, Modèles biologiques, Mutation, Résistance aux substances, Stress physiologique, Techniques in vitro, Végétaux génétiquement modifiés, Xenopus.
English descriptors
- KwdEn :
- Animals (MeSH), Antimalarials (pharmacology), Arabidopsis (genetics), Arabidopsis (metabolism), Arabidopsis Proteins (genetics), Arabidopsis Proteins (metabolism), Cadmium (pharmacology), Chloroquine (pharmacology), Drug Resistance (MeSH), Female (MeSH), Genes, Plant (MeSH), Glutathione (metabolism), Homeostasis (MeSH), In Vitro Techniques (MeSH), Membrane Transport Proteins (genetics), Membrane Transport Proteins (metabolism), Models, Biological (MeSH), Mutation (MeSH), Oocytes (metabolism), Plants, Genetically Modified (MeSH), Plasmodium falciparum (drug effects), Plasmodium falciparum (genetics), Plasmodium falciparum (metabolism), Protozoan Proteins (genetics), Protozoan Proteins (metabolism), Recombinant Proteins (genetics), Recombinant Proteins (metabolism), Stress, Physiological (MeSH), Xenopus (MeSH).
- MESH :
- chemical , genetics : Arabidopsis Proteins, Membrane Transport Proteins, Protozoan Proteins, Recombinant Proteins.
- chemical , metabolism : Arabidopsis Proteins, Glutathione, Membrane Transport Proteins, Protozoan Proteins, Recombinant Proteins.
- chemical , pharmacology : Antimalarials, Cadmium, Chloroquine.
- drug effects : Plasmodium falciparum.
- genetics : Arabidopsis, Plasmodium falciparum.
- metabolism : Arabidopsis, Oocytes, Plasmodium falciparum.
- Animals, Drug Resistance, Female, Genes, Plant, Homeostasis, In Vitro Techniques, Models, Biological, Mutation, Plants, Genetically Modified, Stress, Physiological, Xenopus.
Abstract
In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closely integrated and we show that in Arabidopsis this integration requires a family of three plastid thiol transporters homologous to the Plasmodium falciparum chloroquine-resistance transporter, PfCRT. Arabidopsis mutants lacking these transporters are heavy metal-sensitive, GSH-deficient, and hypersensitive to Phytophthora infection, confirming a direct requirement for correct GSH homeostasis in defense responses. Compartment-specific measurements of the glutathione redox potential using redox-sensitive GFP showed that knockout of the entire transporter family resulted in a more oxidized glutathione redox potential in the cytosol, but not in the plastids, indicating the GSH-deficient phenotype is restricted to the cytosolic compartment. Expression of the transporters in Xenopus oocytes confirmed that each can mediate GSH uptake. We conclude that these transporters play a significant role in regulating GSH levels and the redox potential of the cytosol.
DOI: 10.1073/pnas.0913689107
PubMed: 20080670
PubMed Central: PMC2836691
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses.</title><author><name sortKey="Maughan, Spencer C" sort="Maughan, Spencer C" uniqKey="Maughan S" first="Spencer C" last="Maughan">Spencer C. Maughan</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom. smaughan@venrock.com</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Pasternak, Maciej" sort="Pasternak, Maciej" uniqKey="Pasternak M" first="Maciej" last="Pasternak">Maciej Pasternak</name></author><author><name sortKey="Cairns, Narelle" sort="Cairns, Narelle" uniqKey="Cairns N" first="Narelle" last="Cairns">Narelle Cairns</name></author><author><name sortKey="Kiddle, Guy" sort="Kiddle, Guy" uniqKey="Kiddle G" first="Guy" last="Kiddle">Guy Kiddle</name></author><author><name sortKey="Brach, Thorsten" sort="Brach, Thorsten" uniqKey="Brach T" first="Thorsten" last="Brach">Thorsten Brach</name></author><author><name sortKey="Jarvis, Renee" sort="Jarvis, Renee" uniqKey="Jarvis R" first="Renee" last="Jarvis">Renee Jarvis</name></author><author><name sortKey="Haas, Florian" sort="Haas, Florian" uniqKey="Haas F" first="Florian" last="Haas">Florian Haas</name></author><author><name sortKey="Nieuwland, Jeroen" sort="Nieuwland, Jeroen" uniqKey="Nieuwland J" first="Jeroen" last="Nieuwland">Jeroen Nieuwland</name></author><author><name sortKey="Lim, Benson" sort="Lim, Benson" uniqKey="Lim B" first="Benson" last="Lim">Benson Lim</name></author><author><name sortKey="Muller, Christopher" sort="Muller, Christopher" uniqKey="Muller C" first="Christopher" last="Müller">Christopher Müller</name></author><author><name sortKey="Salcedo Sora, Enrique" sort="Salcedo Sora, Enrique" uniqKey="Salcedo Sora E" first="Enrique" last="Salcedo-Sora">Enrique Salcedo-Sora</name></author><author><name sortKey="Kruse, Cordula" sort="Kruse, Cordula" uniqKey="Kruse C" first="Cordula" last="Kruse">Cordula Kruse</name></author><author><name sortKey="Orsel, Mathilde" sort="Orsel, Mathilde" uniqKey="Orsel M" first="Mathilde" last="Orsel">Mathilde Orsel</name></author><author><name sortKey="Hell, Rudiger" sort="Hell, Rudiger" uniqKey="Hell R" first="Rüdiger" last="Hell">Rüdiger Hell</name></author><author><name sortKey="Miller, Anthony J" sort="Miller, Anthony J" uniqKey="Miller A" first="Anthony J" last="Miller">Anthony J. Miller</name></author><author><name sortKey="Bray, Patrick" sort="Bray, Patrick" uniqKey="Bray P" first="Patrick" last="Bray">Patrick Bray</name></author><author><name sortKey="Foyer, Christine H" sort="Foyer, Christine H" uniqKey="Foyer C" first="Christine H" last="Foyer">Christine H. Foyer</name></author><author><name sortKey="Murray, James A H" sort="Murray, James A H" uniqKey="Murray J" first="James A H" last="Murray">James A H. Murray</name></author><author><name sortKey="Meyer, Andreas J" sort="Meyer, Andreas J" uniqKey="Meyer A" first="Andreas J" last="Meyer">Andreas J. Meyer</name></author><author><name sortKey="Cobbett, Christopher S" sort="Cobbett, Christopher S" uniqKey="Cobbett C" first="Christopher S" last="Cobbett">Christopher S. Cobbett</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20080670</idno><idno type="pmid">20080670</idno><idno type="doi">10.1073/pnas.0913689107</idno><idno type="pmc">PMC2836691</idno><idno type="wicri:Area/Main/Corpus">001964</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001964</idno><idno type="wicri:Area/Main/Curation">001964</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001964</idno><idno type="wicri:Area/Main/Exploration">001964</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses.</title><author><name sortKey="Maughan, Spencer C" sort="Maughan, Spencer C" uniqKey="Maughan S" first="Spencer C" last="Maughan">Spencer C. Maughan</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom. smaughan@venrock.com</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Pasternak, Maciej" sort="Pasternak, Maciej" uniqKey="Pasternak M" first="Maciej" last="Pasternak">Maciej Pasternak</name></author><author><name sortKey="Cairns, Narelle" sort="Cairns, Narelle" uniqKey="Cairns N" first="Narelle" last="Cairns">Narelle Cairns</name></author><author><name sortKey="Kiddle, Guy" sort="Kiddle, Guy" uniqKey="Kiddle G" first="Guy" last="Kiddle">Guy Kiddle</name></author><author><name sortKey="Brach, Thorsten" sort="Brach, Thorsten" uniqKey="Brach T" first="Thorsten" last="Brach">Thorsten Brach</name></author><author><name sortKey="Jarvis, Renee" sort="Jarvis, Renee" uniqKey="Jarvis R" first="Renee" last="Jarvis">Renee Jarvis</name></author><author><name sortKey="Haas, Florian" sort="Haas, Florian" uniqKey="Haas F" first="Florian" last="Haas">Florian Haas</name></author><author><name sortKey="Nieuwland, Jeroen" sort="Nieuwland, Jeroen" uniqKey="Nieuwland J" first="Jeroen" last="Nieuwland">Jeroen Nieuwland</name></author><author><name sortKey="Lim, Benson" sort="Lim, Benson" uniqKey="Lim B" first="Benson" last="Lim">Benson Lim</name></author><author><name sortKey="Muller, Christopher" sort="Muller, Christopher" uniqKey="Muller C" first="Christopher" last="Müller">Christopher Müller</name></author><author><name sortKey="Salcedo Sora, Enrique" sort="Salcedo Sora, Enrique" uniqKey="Salcedo Sora E" first="Enrique" last="Salcedo-Sora">Enrique Salcedo-Sora</name></author><author><name sortKey="Kruse, Cordula" sort="Kruse, Cordula" uniqKey="Kruse C" first="Cordula" last="Kruse">Cordula Kruse</name></author><author><name sortKey="Orsel, Mathilde" sort="Orsel, Mathilde" uniqKey="Orsel M" first="Mathilde" last="Orsel">Mathilde Orsel</name></author><author><name sortKey="Hell, Rudiger" sort="Hell, Rudiger" uniqKey="Hell R" first="Rüdiger" last="Hell">Rüdiger Hell</name></author><author><name sortKey="Miller, Anthony J" sort="Miller, Anthony J" uniqKey="Miller A" first="Anthony J" last="Miller">Anthony J. Miller</name></author><author><name sortKey="Bray, Patrick" sort="Bray, Patrick" uniqKey="Bray P" first="Patrick" last="Bray">Patrick Bray</name></author><author><name sortKey="Foyer, Christine H" sort="Foyer, Christine H" uniqKey="Foyer C" first="Christine H" last="Foyer">Christine H. Foyer</name></author><author><name sortKey="Murray, James A H" sort="Murray, James A H" uniqKey="Murray J" first="James A H" last="Murray">James A H. Murray</name></author><author><name sortKey="Meyer, Andreas J" sort="Meyer, Andreas J" uniqKey="Meyer A" first="Andreas J" last="Meyer">Andreas J. Meyer</name></author><author><name sortKey="Cobbett, Christopher S" sort="Cobbett, Christopher S" uniqKey="Cobbett C" first="Christopher S" last="Cobbett">Christopher S. Cobbett</name></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antimalarials (pharmacology)</term><term>Arabidopsis (genetics)</term><term>Arabidopsis (metabolism)</term><term>Arabidopsis Proteins (genetics)</term><term>Arabidopsis Proteins (metabolism)</term><term>Cadmium (pharmacology)</term><term>Chloroquine (pharmacology)</term><term>Drug Resistance (MeSH)</term><term>Female (MeSH)</term><term>Genes, Plant (MeSH)</term><term>Glutathione (metabolism)</term><term>Homeostasis (MeSH)</term><term>In Vitro Techniques (MeSH)</term><term>Membrane Transport Proteins (genetics)</term><term>Membrane Transport Proteins (metabolism)</term><term>Models, Biological (MeSH)</term><term>Mutation (MeSH)</term><term>Oocytes (metabolism)</term><term>Plants, Genetically Modified (MeSH)</term><term>Plasmodium falciparum (drug effects)</term><term>Plasmodium falciparum (genetics)</term><term>Plasmodium falciparum (metabolism)</term><term>Protozoan Proteins (genetics)</term><term>Protozoan Proteins (metabolism)</term><term>Recombinant Proteins (genetics)</term><term>Recombinant Proteins (metabolism)</term><term>Stress, Physiological (MeSH)</term><term>Xenopus (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antipaludiques (pharmacologie)</term><term>Arabidopsis (génétique)</term><term>Arabidopsis (métabolisme)</term><term>Cadmium (pharmacologie)</term><term>Chloroquine (pharmacologie)</term><term>Femelle (MeSH)</term><term>Glutathion (métabolisme)</term><term>Gènes de plante (MeSH)</term><term>Homéostasie (MeSH)</term><term>Modèles biologiques (MeSH)</term><term>Mutation (MeSH)</term><term>Ovocytes (métabolisme)</term><term>Plasmodium falciparum (effets des médicaments et des substances chimiques)</term><term>Plasmodium falciparum (génétique)</term><term>Plasmodium falciparum (métabolisme)</term><term>Protéines d'Arabidopsis (génétique)</term><term>Protéines d'Arabidopsis (métabolisme)</term><term>Protéines de protozoaire (génétique)</term><term>Protéines de protozoaire (métabolisme)</term><term>Protéines de transport membranaire (génétique)</term><term>Protéines de transport membranaire (métabolisme)</term><term>Protéines recombinantes (génétique)</term><term>Protéines recombinantes (métabolisme)</term><term>Résistance aux substances (MeSH)</term><term>Stress physiologique (MeSH)</term><term>Techniques in vitro (MeSH)</term><term>Végétaux génétiquement modifiés (MeSH)</term><term>Xenopus (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Arabidopsis Proteins</term><term>Membrane Transport Proteins</term><term>Protozoan Proteins</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Arabidopsis Proteins</term><term>Glutathione</term><term>Membrane Transport Proteins</term><term>Protozoan Proteins</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term><term>Cadmium</term><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arabidopsis</term><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Arabidopsis</term><term>Plasmodium falciparum</term><term>Protéines d'Arabidopsis</term><term>Protéines de protozoaire</term><term>Protéines de transport membranaire</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Arabidopsis</term><term>Oocytes</term><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Arabidopsis</term><term>Glutathion</term><term>Ovocytes</term><term>Plasmodium falciparum</term><term>Protéines d'Arabidopsis</term><term>Protéines de protozoaire</term><term>Protéines de transport membranaire</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antipaludiques</term><term>Cadmium</term><term>Chloroquine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Resistance</term><term>Female</term><term>Genes, Plant</term><term>Homeostasis</term><term>In Vitro Techniques</term><term>Models, Biological</term><term>Mutation</term><term>Plants, Genetically Modified</term><term>Stress, Physiological</term><term>Xenopus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Gènes de plante</term><term>Homéostasie</term><term>Modèles biologiques</term><term>Mutation</term><term>Résistance aux substances</term><term>Stress physiologique</term><term>Techniques in vitro</term><term>Végétaux génétiquement modifiés</term><term>Xenopus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closely integrated and we show that in Arabidopsis this integration requires a family of three plastid thiol transporters homologous to the Plasmodium falciparum chloroquine-resistance transporter, PfCRT. Arabidopsis mutants lacking these transporters are heavy metal-sensitive, GSH-deficient, and hypersensitive to Phytophthora infection, confirming a direct requirement for correct GSH homeostasis in defense responses. Compartment-specific measurements of the glutathione redox potential using redox-sensitive GFP showed that knockout of the entire transporter family resulted in a more oxidized glutathione redox potential in the cytosol, but not in the plastids, indicating the GSH-deficient phenotype is restricted to the cytosolic compartment. Expression of the transporters in Xenopus oocytes confirmed that each can mediate GSH uptake. We conclude that these transporters play a significant role in regulating GSH levels and the redox potential of the cytosol.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20080670</PMID><DateCompleted><Year>2010</Year><Month>03</Month><Day>05</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN><JournalIssue CitedMedium="Internet"><Volume>107</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>Feb</Month><Day>02</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation></Journal><ArticleTitle>Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses.</ArticleTitle><Pagination><MedlinePgn>2331-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1073/pnas.0913689107</ELocationID><Abstract><AbstractText>In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closely integrated and we show that in Arabidopsis this integration requires a family of three plastid thiol transporters homologous to the Plasmodium falciparum chloroquine-resistance transporter, PfCRT. Arabidopsis mutants lacking these transporters are heavy metal-sensitive, GSH-deficient, and hypersensitive to Phytophthora infection, confirming a direct requirement for correct GSH homeostasis in defense responses. Compartment-specific measurements of the glutathione redox potential using redox-sensitive GFP showed that knockout of the entire transporter family resulted in a more oxidized glutathione redox potential in the cytosol, but not in the plastids, indicating the GSH-deficient phenotype is restricted to the cytosolic compartment. Expression of the transporters in Xenopus oocytes confirmed that each can mediate GSH uptake. We conclude that these transporters play a significant role in regulating GSH levels and the redox potential of the cytosol.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maughan</LastName><ForeName>Spencer C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom. smaughan@venrock.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pasternak</LastName><ForeName>Maciej</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Cairns</LastName><ForeName>Narelle</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Kiddle</LastName><ForeName>Guy</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Brach</LastName><ForeName>Thorsten</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Jarvis</LastName><ForeName>Renee</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Haas</LastName><ForeName>Florian</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Nieuwland</LastName><ForeName>Jeroen</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Benson</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Salcedo-Sora</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Kruse</LastName><ForeName>Cordula</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Orsel</LastName><ForeName>Mathilde</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hell</LastName><ForeName>Rüdiger</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Anthony J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Bray</LastName><ForeName>Patrick</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Foyer</LastName><ForeName>Christine H</ForeName><Initials>CH</Initials></Author><Author ValidYN="Y"><LastName>Murray</LastName><ForeName>James A H</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>Andreas J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Cobbett</LastName><ForeName>Christopher S</ForeName><Initials>CS</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>BBS/E/C/00004166</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>BB/C515047/1</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>BB/C51508X/1</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>01</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Proc Natl Acad Sci U S A</MedlineTA><NlmUniqueID>7505876</NlmUniqueID><ISSNLinking>0027-8424</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029681">Arabidopsis Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D026901">Membrane Transport Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C416369">PfCRT protein, Plasmodium falciparum</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015800">Protozoan Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>00BH33GNGH</RegistryNumber><NameOfSubstance UI="D002104">Cadmium</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>GAN16C9B8O</RegistryNumber><NameOfSubstance UI="D005978">Glutathione</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017360" MajorTopicYN="N">Arabidopsis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029681" MajorTopicYN="N">Arabidopsis Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002104" MajorTopicYN="N">Cadmium</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004351" MajorTopicYN="N">Drug Resistance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017343" MajorTopicYN="N">Genes, Plant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005978" MajorTopicYN="N">Glutathione</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D026901" MajorTopicYN="N">Membrane Transport Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009865" MajorTopicYN="N">Oocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010963" MajorTopicYN="N">Plasmodium falciparum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015800" MajorTopicYN="N">Protozoan Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014981" MajorTopicYN="N">Xenopus</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>3</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20080670</ArticleId><ArticleId IdType="pii">0913689107</ArticleId><ArticleId IdType="doi">10.1073/pnas.0913689107</ArticleId><ArticleId IdType="pmc">PMC2836691</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Plant Cell. 2000 Jan;12(1):97-110</Citation><ArticleIdList><ArticleId IdType="pubmed">10634910</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9109-14</Citation><ArticleIdList><ArticleId IdType="pubmed">19451637</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2001 Mar 23;276(12):8648-56</Citation><ArticleIdList><ArticleId IdType="pubmed">11115509</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2001 Apr 17;20(8):1875-87</Citation><ArticleIdList><ArticleId IdType="pubmed">11296221</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2001 Jul;27(1):67-78</Citation><ArticleIdList><ArticleId IdType="pubmed">11489184</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Plant Sci. 2001 Oct;6(10):486-92</Citation><ArticleIdList><ArticleId IdType="pubmed">11590068</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2001 Nov;28(3):293-305</Citation><ArticleIdList><ArticleId IdType="pubmed">11722772</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2002 Oct 4;298(5591):210-3</Citation><ArticleIdList><ArticleId IdType="pubmed">12364805</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem J. 2002 Dec 15;368(Pt 3):761-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12225291</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 2002 Dec;130(4):1927-37</Citation><ArticleIdList><ArticleId IdType="pubmed">12481075</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2003 Jun 27;113(7):935-44</Citation><ArticleIdList><ArticleId IdType="pubmed">12837250</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Microbiol. 2004 Mar;2(3):203-16</Citation><ArticleIdList><ArticleId IdType="pubmed">15083156</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2004 Sep;16(9):2448-62</Citation><ArticleIdList><ArticleId IdType="pubmed">15308753</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Biol Evol. 2004 Oct;21(10):1938-49</Citation><ArticleIdList><ArticleId IdType="pubmed">15240840</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Enzymol. 1992;207:266-79</Citation><ArticleIdList><ArticleId IdType="pubmed">1528120</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 1995 Apr;107(4):1067-73</Citation><ArticleIdList><ArticleId IdType="pubmed">7770518</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Enzymol. 1995;252:26-30</Citation><ArticleIdList><ArticleId IdType="pubmed">7476360</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1996 Jun 6;381(6582):482</Citation><ArticleIdList><ArticleId IdType="pubmed">8632819</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8243-8</Citation><ArticleIdList><ArticleId IdType="pubmed">9223346</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12049-54</Citation><ArticleIdList><ArticleId IdType="pubmed">9751788</ArticleId></ArticleIdList></Reference><Reference><Citation>Anal Biochem. 1998 Nov 1;264(1):98-110</Citation><ArticleIdList><ArticleId IdType="pubmed">9784193</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2004 Nov 12;306(5699):1183-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15539603</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2005 Jan;41(1):15-30</Citation><ArticleIdList><ArticleId IdType="pubmed">15610346</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2005 Feb;41(3):442-50</Citation><ArticleIdList><ArticleId IdType="pubmed">15659102</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Plant Biol. 2005;56:187-220</Citation><ArticleIdList><ArticleId IdType="pubmed">15862094</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2005 Jul;17(7):1866-75</Citation><ArticleIdList><ArticleId IdType="pubmed">15987996</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Genet. 2005 Oct;37(10):1130-4</Citation><ArticleIdList><ArticleId IdType="pubmed">16170317</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16478-83</Citation><ArticleIdList><ArticleId IdType="pubmed">16263928</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Physiol. 2006 Jun;141(2):446-55</Citation><ArticleIdList><ArticleId IdType="pubmed">16531482</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2006 Jun 30;312(5782):1882-3</Citation><ArticleIdList><ArticleId IdType="pubmed">16809515</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2006 Sep 15;281(37):27557-65</Citation><ArticleIdList><ArticleId IdType="pubmed">16766527</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2007 Jan;49(1):159-72</Citation><ArticleIdList><ArticleId IdType="pubmed">17144898</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10270-5</Citation><ArticleIdList><ArticleId IdType="pubmed">17540731</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant Cell. 2007 Aug;19(8):2653-61</Citation><ArticleIdList><ArticleId IdType="pubmed">17766407</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2007 Dec;52(5):973-86</Citation><ArticleIdList><ArticleId IdType="pubmed">17892447</ArticleId></ArticleIdList></Reference><Reference><Citation>Plant J. 2008 Mar;53(6):999-1012</Citation><ArticleIdList><ArticleId IdType="pubmed">18088327</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Genet. 2008 May;9(5):383-95</Citation><ArticleIdList><ArticleId IdType="pubmed">18368053</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Methods. 2008 Jun;5(6):553-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18469822</ArticleId></ArticleIdList></Reference><Reference><Citation>J Microsc. 2008 Aug;231(2):299-316</Citation><ArticleIdList><ArticleId IdType="pubmed">18778428</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9931-6</Citation><ArticleIdList><ArticleId IdType="pubmed">10954735</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Brach, Thorsten" sort="Brach, Thorsten" uniqKey="Brach T" first="Thorsten" last="Brach">Thorsten Brach</name><name sortKey="Bray, Patrick" sort="Bray, Patrick" uniqKey="Bray P" first="Patrick" last="Bray">Patrick Bray</name><name sortKey="Cairns, Narelle" sort="Cairns, Narelle" uniqKey="Cairns N" first="Narelle" last="Cairns">Narelle Cairns</name><name sortKey="Cobbett, Christopher S" sort="Cobbett, Christopher S" uniqKey="Cobbett C" first="Christopher S" last="Cobbett">Christopher S. Cobbett</name><name sortKey="Foyer, Christine H" sort="Foyer, Christine H" uniqKey="Foyer C" first="Christine H" last="Foyer">Christine H. Foyer</name><name sortKey="Haas, Florian" sort="Haas, Florian" uniqKey="Haas F" first="Florian" last="Haas">Florian Haas</name><name sortKey="Hell, Rudiger" sort="Hell, Rudiger" uniqKey="Hell R" first="Rüdiger" last="Hell">Rüdiger Hell</name><name sortKey="Jarvis, Renee" sort="Jarvis, Renee" uniqKey="Jarvis R" first="Renee" last="Jarvis">Renee Jarvis</name><name sortKey="Kiddle, Guy" sort="Kiddle, Guy" uniqKey="Kiddle G" first="Guy" last="Kiddle">Guy Kiddle</name><name sortKey="Kruse, Cordula" sort="Kruse, Cordula" uniqKey="Kruse C" first="Cordula" last="Kruse">Cordula Kruse</name><name sortKey="Lim, Benson" sort="Lim, Benson" uniqKey="Lim B" first="Benson" last="Lim">Benson Lim</name><name sortKey="Meyer, Andreas J" sort="Meyer, Andreas J" uniqKey="Meyer A" first="Andreas J" last="Meyer">Andreas J. Meyer</name><name sortKey="Miller, Anthony J" sort="Miller, Anthony J" uniqKey="Miller A" first="Anthony J" last="Miller">Anthony J. Miller</name><name sortKey="Muller, Christopher" sort="Muller, Christopher" uniqKey="Muller C" first="Christopher" last="Müller">Christopher Müller</name><name sortKey="Murray, James A H" sort="Murray, James A H" uniqKey="Murray J" first="James A H" last="Murray">James A H. Murray</name><name sortKey="Nieuwland, Jeroen" sort="Nieuwland, Jeroen" uniqKey="Nieuwland J" first="Jeroen" last="Nieuwland">Jeroen Nieuwland</name><name sortKey="Orsel, Mathilde" sort="Orsel, Mathilde" uniqKey="Orsel M" first="Mathilde" last="Orsel">Mathilde Orsel</name><name sortKey="Pasternak, Maciej" sort="Pasternak, Maciej" uniqKey="Pasternak M" first="Maciej" last="Pasternak">Maciej Pasternak</name><name sortKey="Salcedo Sora, Enrique" sort="Salcedo Sora, Enrique" uniqKey="Salcedo Sora E" first="Enrique" last="Salcedo-Sora">Enrique Salcedo-Sora</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Maughan, Spencer C" sort="Maughan, Spencer C" uniqKey="Maughan S" first="Spencer C" last="Maughan">Spencer C. Maughan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PhytophthoraV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001857 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001857 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PhytophthoraV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:20080670
|texte= Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20080670" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PhytophthoraV1
| This area was generated with Dilib version V0.6.38. |  |